Lysolecithin metabolism by human platelets.
نویسندگان
چکیده
Human platelets incubated with 32p lysolecithin convert this compound to platelet lecithin and the water-soluble product glycerylphosphorylcholine. Lecithin synthesis from lysolecithin by intact platelets has a pH optimum of 9, whereas platelet homogenates show a pH optimum of 7.5 for the same reaction. Conversion of lysolecithin to platelet lecithin takes place by direct acylation of lysolecithin with free fatty acid. Addition of thrombin or ADP to the incubation medium has no effect on lysolecithin acylalion or breakdown and does not affect the degradation of ‘4C choline-labeled platelet lecithin. Polystyrene particles stimulate lecithin synthesis and lysolecithin breakdown to glyceryiphosphorylcholine by intact platelets but have no effect when added to platelet homogenates. By converting lysolecithin to lecithin, platelets add 2% to their lecithin content in 1 hr.
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ورودعنوان ژورنال:
- Blood
دوره 37 6 شماره
صفحات -
تاریخ انتشار 1971